Lymphocytic Thyroiditis and Diabetes in the BB/W Rat: A New Model of Autoimmune Endocrinopathy
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Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy.
The Bio Breeding/Worcester (BB/W) rat develops spontaneous insulin-dependent diabetes mellitus secondary to lymphocytic infiltration and destruction of the pancreatic beta-cells. This destructive process in the pancreas has been postulated to be based on a thymus-dependent cell-mediated autoimmune process. In view of the well recognized association in man of diabetes mellitus and another autoim...
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15 صفحه اولExpression of tenascin in lymphocytic autoimmune thyroiditis.
AIMS To study the distribution of tenascin by immunocytochemistry in autoimmune diseases of the thyroid. METHODS Thyroids from patients with inflammatory lesions of the thyroid (lymphocytic thyroiditis Hashimoto, Grave's disease, thyroiditis DeQuervain) were studied by immunocytochemistry using antibodies against tenascin, collagen III, and collagen IV. RESULTS In autoimmune lymphocytic thy...
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Introduction Certain individuals and families seem to be unusually prone to develop organ-specific autoimmune disorders. The conditions which appear most closely associated are thyroid disease (Hashimoto's thyroiditis, thyrotoxicosis or primary hypothyroidism), Addison's disease, hypoparathyroidism and pernicious anaemia. A number of other conditions may also be associated including diabetes me...
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Recorded observations suggest strongly but not conclusively that auto-immunity is a factor in the pathogenesis of at least some forms of juvenile diabetes mellitus. This view is based on the occasional association of juvenile diabetes with Hashimoto's disease, which is a well-known example of auto-immunity, the presence of thyroid antibodies in some cases of diabetes, and the pathohistological ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1981
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.30.12.1058